October 04, 2023
1 min read
Source/Disclosures
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Disclosures:
Grams reports receiving nonfinancial support from Kidney Disease: Improving Global Outcomes, and Korean Society of Nephrology, and personal fees Nephrology Self-Assessment Program. Please see the full study for other authors’ relevant financial disclosures.
Key takeaways:
- Mean eGFR of 90 mL/min/1.73 m² was linked with adverse outcomes in the patients using creatinine alone.
- Lower eGFR and more severe albuminuria were linked to adverse cardiovascular outcomes.
Lower eGFR and severe albuminuria may be linked with higher rates of adverse kidney and cardiovascular outcomes, including death, according to a recently published study.
The comprehensive meta-analysis, which included data from more than 27 million people from 114 global cohorts, examined the association between chronic kidney disease markers, such as eGFR, albuminuria and various health outcomes.
Mean eGFR of 90 mL/min/1.73 m² was linked with adverse outcomes in the patients using creatinine alone. Image: Adobe Stock.
“CKD affects approximately 14% of adults in the U.S.,” Morgan E. Grams, MD, PhD, of the Writing Group for the CKD Prognosis Consortium, and colleagues wrote. “Lower eGFR values and more severe albuminuria were associated with multiple adverse outcomes.”
Researchers ran the retrospective individual-level data analysis from 1980 to 2021. Participants were evaluated based on eGFR calculated using creatinine alone or creatinine combined with cystatin C, as well as albuminuria estimated as urine albumin-to-creatinine ratio (UACR). Data included analysis of 27,503,140 adults from 114 global cohorts with creatinine-based eGFR; 720,736 from 20 creatinine-and-cystatin C cohorts; and 9,067,753 from 114 albuminuria-based cohorts.
Researchers considered outcomes as kidney failure risk requiring replacement therapy, all-cause mortality, cardiovascular mortality, AKI, hospitalization, coronary heart disease, stroke, heart failure, atrial fibrillation and peripheral artery disease.
According to the results, mean eGFR of 90 mL/min/1.73 m² was associated with adverse outcomes in the population using creatinine alone. The population using eGFR based on creatinine and cystatin C had a mean eGFR of 88 mL/min/1.73 m². Lower eGFR and more severe albuminuria were also linked to adverse cardiovascular outcomes, such as cardiovascular death, heart failure and atrial fibrillation, according to the study.
